Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes COVID-19 disease, has become a global health threat since its emergence. Healthcare workers are at the frontline defense against the COVID-19 pandemic. Therefore, this study was conducted to explore the predictors of quality of life of frontline health care workers caring for COVID-19 patients in Lagos State.The study was adopted a quantitative design, using descriptive cross-sectional method. The population for this study consisted of Nurses, Doctors and Hygienists caring for covid-19 patients at the covid-19 isolation centers of Lagos University Teaching Hospital (LUTH), Infectious Disease Hospital (IDH) and First Cardiology Consultant Hospital in Lagos State. A convenience sample of 150 frontline health care workers were selected. A structured questionnaire adapted from WHO was used to collect data. The research questions were answered via descriptive statistics while inferential statistics were used to test the formulated hypotheses. From the result, it can be observed that the respondents had a good level of knowledge of COVID-19. Over an average of respondents 99(67.8%) showed positive attitude.  Regarding the QoL, the respondents scored a mean of 71.4±12.3 this gives the quality-of-life score of 75.9%.  Findings further showed that there is a significant relationship between age and the quality of life (X²= 379.863; P= 0.000). The level of the respondents’ knowledge of infection control has a negative significant prediction on quality of life (β= -.902, t= 9.455; P= 0.00). The level of knowledge has 5.2% (R²= 0.052) level of prediction on quality of life. The study concluded that the healthcare workers in Lagos State have good knowledge of COVID-19 infection as more than half of the respondents had good knowledge of infection and that that majority of respondents had positive attitude towards COVID-19 in Lagos State. It was found that younger nurses, unmarried workers, males and workers with higher years of experienced reported better quality of life than their counterparts.

Keywords: Attitude, COVID-19, Healthcare workers, Knowledge, Quality of Life,

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